Paul Larsmon:
As far as big pharma is concerned, I mean there seem to be some very stark differences in the way they're going forward and we've got Pfizer making a big take over, we've got Eli Lilly saying oh no, no that's not the way forward that, that doesn't get any value at all for the shareholders, I mean somebody's got be wrong here and somebody's got to be right?
Seigfried Bialojan:
Well I think is not a wrong or right, there are many solutions to the problem. I think what we have analyzed and described in recent times is what we call a finance transformation especially in the pharma industry, which means if you look at pharma 10, 15-years back it was mostly top line growth that was relevant, now we are talking about cost containment in the health system about shrinking margins and things like that, which has turned them around into a more bottom line oriented course and that means saving money if you cannot really put on more revenues, right? So, well still some of them put -- try to put on more revenue by buying pipelines. We think this is probably a more short sighted you to do that, you know it's short-term fixes, short-term fixes to provide growth potential with a pipeline that is growing of course, right? I think in the long run it will need more sustainable solutions that's actually what we really just have analyzed a lot and part of that is sustainable solutions we do see also, right? It's in the organization, that's if you look at company like GSK , like Eli Lilly as well how they organize their R&D in order to catch up with innovation, right? There are some movements in these organization, so it's not only buying pipelines there is a lot going on in order to get over this point of, of reaching the R&D innovation gap and things like that. So and it's , as I said it's not true there is not a black and white, I think all these elements have to be kind of mixed to find out what can we for a individual company use as a best practice Which fits to our organization and it's not that each one of these concepts fits to any of these companies, and may be one point talking about longer sustainable solutions, longer-term sustainable solutions is instead of just buying pipelines we see a lot of activities going into platforms, so platforms have a more long-term perspective to provide product of the future and provide innovative product on an ongoing basis. So this is certainly a big trend that we see to get over this productivity crisis, and I think it's also the fact that many of these companies, pharma companies realize the collaboration with biotech's to be, become more relevant, more essential, Couple of other things.